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HRS 2019: MADIT trials analysis shows decline in sudden cardiac deaths “likely due to CRT”

Valentina Kutyifa (Rochester, USA) discusses the late-breaking study findings looking at data from the family of MADIT (Multicenter Automatic Defibrillator) trials.

Kutyifa told Cardiac Rhythm News that the key takeaway from the analysis of the trials’ data was that cardiac resynchronisation therapy (CRT) was found to be “associated with a reduction in the risk of life-threatening ventricular arrhythmia events.”

A sub-group analysis of the trials focusing on patients that had narrow QRS and an indication for an ICD (implantable cardioverter-defibrillator) showed that there was “no difference in the rate of life-threatening ventricular arrhythmias in the earlier MADIT studies compared with the later studies”. Despite these findings however, Kutyifa notes that ICD is “still a very valuable therapy for patients with a narrow QRS to save lives from sudden cardiac death”.

According to Kutyifa the study is “really important” because it shows that the decline of sudden cardiac deaths and potential ventricular arrhythmia events is “likely due to CRT devices”.

Kutyifa, Valentina

Valentina Kutyifa is an Associate Professor of Medicine at the University of Rochester Medical Center, New York, USA. Kutyifa holds a PhD in cardiac electrophysiology, a Masters'​ degree in health care management, and a certificate in clinical research from Harvard Medical School, and has a research interest in cardiac arrhythmias and sudden cardiac death.

Her research work encompasses a wide array of studies related to diabetes, implantable cardioverter–defibrillators, cardiac resynchronization therapy, echocardiography, and technology innovations including the wearable cardioverter–defibrillator, subcutaneous ICD, left ventricular assist devices, and new disruptive wearable technologies improving health care delivery.

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