ESVS 2019: HT-CLI trial to definitively test if cell technology can salvage limbs in CLI patients

Bijan Modarai (London, UK) talks to BLearning Peripheral at ESVS 2019 (European Society for Vascular Surgery; 24–27 September; Hamburg, Germany) about the HT-CLI trial, which will look at the efficacy of a novel blood filtration technology that is aimed at using cells that are capable of growing new blood vessels to treat critical limb ischaemia (CLI) patients who do not have surgical or endovascular revascularisation options.

Modarai says this new study–which will enrol 350 patients in multiple sites around the world with close follow-up, including wound imaging for up to 12-months–is aimed at “addressing all the shortcomings” of previously “unsuccessful” smaller trials.

Modarai explains this is a large randomised controlled study, delivering a sustained population of cells, and seeks to definitively answer whether this type of approach is able to “salvage the limb or not”.

Modarai, Bijan

Bijan Modarai is a Professor of Vascular Surgery at Kings Health Partners and a British Heart Foundation (BHF) Senior Clinical Research Fellow. He completed his Basic Surgical Training in London before being awarded a BHF Clinical PhD Studentship in 2002. He graduated with a PhD in Biochemistry in 2006 and completed his Higher Surgical Training as an NIHR Academic Clinical Lecturer at King's and as an Endovascular Fellow at The Royal Prince Alfred Hospital in Sydney. He was appointed as a Senior Lecturer in Vascular Surgery at King's and Honorary Consultant Vascular Surgeon at GSTT in 2012, having secured a BHF Intermediate Clinical Research Fellowship. He was awarded a Hunterian Professorship by The Royal College of Surgeons of England in 2017.

He is a Council member of the British Society for Endovascular Therapy, examines for the Fellowship of European Board of Vascular Surgery and co-leads the GSTT/King's Biomedical Research Centre School of Translational & Experimental Medicine.

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