LEOPARD trial three-year data provide head-to-head comparison of AFX2 with other endografts

Christopher Kwolek (Boston, USA) talks to VEITHtv about the “truly revolutionary” LEOPARD trial which evaluated the AFX EVAR AAA Graft System (Endologix) with anatomical fixation against a range of other approved endovascular systems with proximal fixation. The three-year data show that AFX has “absolutely the same” durability, safety and efficacy as other commonly commercially available devices in the US, he says.

Kwolek emphasises that LEOPARD is the only randomised controlled trial (RCT) with contemporary comparative EVAR data and points out that the three-year results showed no difference between AFX2 and other devices, with regard to important outcomes including a composite endpoint (that included periprocedural, death, rupture, conversion to open surgical repair and other events), freedom from aneurysm-related complications, freedom from type I, II and III endoleak and freedom from all-cause and aneurysm-related mortality.

These results are “vitally important” because for the first time this “gives us a contemporary control group for all future EVAR and endovascular device trials designed to treat aneurysms”, adds Kwolek, while he discusses the need to continue pursuing high quality Level 1 evidence to “truly make the best, most informed decisions to benefit our patients”.

This video is sponsored by Endologix.

Kwolek, Christopher

Christopher Kwolek graduated from the University of California, San Francisco Medical School in 1987. He completed his general surgery training at the Harvard/Deaconess Surgical Service in 1993, his Vascular Surgery fellowship at the MGH in 1995 and an advanced endovascular fellowship at the Arizona Heart Institute.

After serving on the faculty at the University of Kentucky as the Chief of Vascular Surgery and the training program director, he was recruited back to the MGH in 1992. He served as the Director of the Vascular and Endovascular Training program at the MGH and as the Chief of Vascular Surgery at the Newton-Wellesley Hospital until 2016 when Dr. Kwolek was recruited to become the Chair of the Department of Surgery at Newton-Wellesley Hospital while maintaining a complex vascular surgery practice at the MGH.

Add comment

Editor’s Aortic Pick

    Subscribe to receive the very best in medical videos

    /* ]]> */